 TRB proteins have been shown to recruit PRC2 for H3K27 Me3 deposition. This work shows that TRBs also recruit JMJ14 to remove H3K4 Me3, demonstrating that TRBs silenced the target genes via a combinatorial histone modification mechanism. This article was authored by Ming Wang, Jin Huizhong, Javier Gallego Batolome, and others.