 The receptor for advanced glycation end products, RAGE, is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. Ligand-RAGE interactions trigger a series of signal-transduction cascades and lead to the activation of transcription factor NFB and increased expression of cytokines, chemokines, and adhesion molecules. This results in the initiation of inflammation and the perpetuation of inflammatory responses. RAGE has been implicated in a variety of inflammatory-related pathological conditions including arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite recent advances in understanding the molecular mechanisms by which RAGE signaling contributes to these conditions, further research is needed to fully realize its potential clinical significance. This article was authored by your Kwong Chua, Rosalisa Bacer, Hernie Talibe, and others.