 Gout has been associated with lower brain volume and higher levels of brain iron, as well as increased risks for dementia, Parkinson's disease and essential tremor. The association was strongest within the first three years following a gout diagnosis, suggesting that gout may be causally linked to these conditions. This suggests that gout may have a direct effect on brain health, potentially through its effects on inflammation or other mechanisms. This article was authored by Anya Topiwala, Kulvia Mankia, Steven Bell, and others.