 The introduction of rotavirus vaccines in high-income countries has been successful in reducing hospitalizations due to rotavirus infection. However, the optimal timing and level of vaccine coverage for maximum economic benefit remains unclear. This study examined the short and long-term economic impact of rotavirus vaccination in Belgium, comparing the results to pre-launch predictions. The authors found that the observed data was more favorable than the pre-launch predictions in the short term, but less so in the long term. They also found that a simulated optimal launch of rotavirus vaccination could lead to significant economic gains over time.