 CO2 nanoparticles with a size range of 160 nanometers, prepared using soljo process, were found to protect gastrointestinal mucosal from ethanol induced gastric ulcers in an animal model. The ability of these nanoparticles to protect ulcers was supported by increased amounts of biomarkers like SOD and catalase in the native tissue. The prepared nanoparticles were characterized by SEM and XRD, and their probable mechanism may be due to the dual-oxidation state of CO2 which helps in scavenging reactive oxygen species and reducing oxidative stress locally. These results suggest that CO2 nanoparticles could be useful in protecting gastrointestinal mucosa from oxidative stress generated by ethanol. This article was authored by Rangabatla Gunswera Subramaniyavara Prasad, Refthi Devan, Shankar Jyothi, and others.