 This systematic review found that hemodialysis patients have lower antibody levels following mRNA SARS-CoV-2 vaccination compared to healthy individuals. Chronic kidney disease patients had the highest antibody levels, followed by hemodialysis patients and then kidney transplant recipients. These findings suggest that robust vaccination strategies are necessary for vulnerable populations such as hemodialysis patients. This article was authored by Kinn Israel Nadarte, Jesus Alfonso Catae, Princess Junire Peligro and others.