 This 50-year-old female with brulee ulcer developed a skin rush after starting streptomycin and revampicin. The most likely cause of this rush is revampicin. Several side effects have been documented from the use of revampicin. GI side effects which include nausea, vomiting and abdominal pain, liver problems such as jaundice and development or abnormalities in the liver function tests and also renal function abnormalities and commonly there have been skin problems. Often patients will present with rushes or exfoliative dermatitis and in some cases toxic epidermal necrolases. The best option following such reaction is to stop the medication. After symptoms have resolved in this case it is unwise to restart the medication.