 The Recruitment Innovation Centre, IC, was established as part of the Trial Innovation Network, TIN, to address the challenge of low enrollment rates in clinical trials. The IC works closely with investigators and Clinical and Translational Science Award, CTSA, institutions to develop and test new approaches to recruiting participants and retaining them throughout the course of a trial. The IC has provided tailored recruitment support to 173 studies, including feasibility assessments, community input sessions, social media campaigns and other resources. Additionally, the IC has developed a virtual toolbox of resources available online, as well as hosting regular webinars to share best practices and lessons learned from their work. This article was authored by Consuelo H. Wilkins, Terri L. Edwards, Mary Stroud and others.