 Introduction Monkeypox is a rare zoonotic disease caused by a virus belonging to the orthopox virus genus and is closely related to smallpox and cowpox viruses. It can be transmitted from animals to humans and is characterized by fever, headache, muscle aches and a rash. The emerging epidemic amidst the COVID-19 pandemic is a cause for concern and requires urgent public health attention. AIM to explore the emerging zoonotic, epidemic threats, future implications and the way ahead in respect of monkeypox. Methodology, secondary data from official government sites, press information, latest articles, newspapers and the World Health Organization, WHO website were extracted and discussed in the article. The current epidemiology of monkeypox with the differences from the COVID-19 pandemic is highlighted in the study. The most probable factors for the emergence and recent outbreak are also discussed. The period of the study was from 20 May 2022 to 27 May 2022 and was conducted in the medical. This article was authored by Suraj Kapoor and Ashwin Vartharajan. We are article.tv, links in the description below.