 This study found that oral st. John's wort, hyperacomperforatum, had a more positive effect on problematic wounds compared with topical st. John's wort and olive oil, which was used as a vehicle. The results showed faster inflammatory response and better healing in the oral st. John's wort group. These findings could contribute to the literature about the clinical usage of hyperacomperforatum on diabetic wounds. This article was offered by Mehmet Al-Parmak and Tia Minescatasalu.