 Piper sarmentosum is a traditional herbal plant that has been studied extensively for its multiple biological activities, including antimicrobial, anticancerous, and anti-hyperglycemic properties. In our study, we investigated whether this plant could be used to induce osteoblast differentiation of human peripheral blood stem cells. We found that the ethanolic extract of Piper sarmentosum significantly enhanced the proliferation of the cells and induced the expression of osteogenic markers. Furthermore, the extract contains several compounds that are known to promote osteoblast differentiation, suggesting that it may be useful in treating bone disorders. This article was authored by Intensirina Zainal Abedin, Amis Nabila Johari, Muhammad Dain Yassid, and others.