 In summary, few and incomplete reports were found regarding oral lesions in pediatric SARS-CoV-2 positive patients. Most lesions were not specific or inaccurately described. Oral lesions in pediatric SARS-CoV-2 positive patients included erosive ulcerative lesions and macules slash patikii, primarily erythematous. After COVID-19 vaccination, oral adverse reactions were rare and typically presented as erosive ulcerative lesions with EM-like or unspecified patterns. Further research is needed to better understand these oral lesions in pediatric SARS-CoV-2 positive patients and after COVID-19 vaccination. This knowledge could help clinicians provide improved multidisciplinary pediatric oral and general care. This article was authored by Federica de Spirito, Francesco D'Ambrosio, Maria Pia di Palo and others.