 Senegal has successfully introduced a nationwide human papillomavirus, HPV, vaccination program, making it one of the first countries in Africa to do so. The program was well received by community stakeholders who reported high levels of acceptance and understanding of the vaccine's purpose and target population. Additionally, the majority of respondents had been trained on the vaccine prior to its implementation, which helped ensure successful integration of the vaccine into existing immunization services. Despite these successes, further technical support will be necessary to maintain the program's sustainability. This article was authored by Rina H. Doshi, Rebecca M. Casey, Nanji Adrien, and others.