 A novel membrane-targeted aggregation-induced emission photosensitizer, TBTC-PQY, is developed for highly efficient photodynamic therapy, PDT, of candidiasis, which efficiently targets oral and vulvovaginal candidiasis in vivo, induces immune response, relieves inflammation, accelerates healing, and demonstrates excellent biocompatibility. This article was authored by Mingyu Wu, Xiao Yousu, Ruihu, and others.