 This study examined the experience of nine global jurisdictions that engaged primary care providers, PCPs, to administer COVID-19 vaccinations during the pandemic. It also described how vaccine hesitancy and principles of equity were incorporated into the vaccine rollout strategies and identified the barriers and facilitators to the vaccine rollout. The vaccine distribution approach started at hospitals in most jurisdictions, with PCPs being engaged later on. Equity was considered in the prioritization policies for various marginalized groups. Vaccine hesitancy was not explicitly considered in the design of vaccine distribution approaches. The rollout of vaccines was facilitated by having established policies and processes for pandemic preparedness, well-established and coordinated information systems, primary care interventions, adequate supply of providers, education, and training of providers and effective communication strategies. Further research is needed to evaluate the impact of a primary care-led vaccine distribution approach on vaccine hesitancy, adoption, and equity. This article was authored by Richard H. Glacier, Alan Katz, Ross E. G. Upsher, and others. We are article.tv, links in the description below.