 This research paper examines the role of circular RNA, CERC RNA, in the progression of osteoarthritis. It was found that CERC RNA can regulate the expression of genes such as TGF2, which plays a key role in the development of osteoarthritis. Additionally, it was discovered that CERC RNA can increase the production of TGF2 by sponging mere 1208, which leads to increased phosphorylation of SMAD-15 incondrocytes. This process ultimately results in the progression of osteoarthritis. Furthermore, it was shown that intraarticular injection of chesacrab, a short hairpin RNA, CERC RNA, designed to block the expression of CERC RNA, could reduce the severity of osteoarthritis in mice. These findings suggest that CERC RNA may be a promising therapeutic target for treating osteoarthritis. This article was authored by Yang Xiu, Thuping Mao, Zhen Bo Long, and others.