 Metal nanoparticles, N-piece, specifically silver and gold N-piece, have shown promising results in various medical and industrial applications due to their unique physical chemical properties. They have potential as effective anti-cancer, anti-inflammatory, and antimicrobial agents, drug delivery systems, and imaging agents for diagnosing and treating a variety of disorders. Over 30 clinical investigations have assessed their biocompatibility and safety in administering either silver or gold N-piece in conditions ranging from nosocomial infections to different types of cancers. The present review highlights the potential of silver and gold N-piece as innovative and effective therapeutics in biomedicine, citing some of their most relevant current applications. This article was authored by Ana Flavia Berlek, Andrea Corsiova, Monica Boeve, and others.