 Hello everyone we're live and it's so awesome of you to join me. I know I did advertise this with my practitioner newsletter which is a pretty large group of people so you might be joining me from all over. If you're a practitioner you're in for a huge treat today as you always know with Bob Miller we go deep and we go technical. If you're just a person who found us on Facebook and doesn't know what you're getting into be ready for a ride because this isn't for the lightweight. We're going to go deep into genetic pathways and paryoxynitrate and some really amazing things but I promise you it'll be interesting. So I want to introduce our guest first and then I want to ask him a few basic questions and then we'll dive right in and he actually even has some slides to share because when we're dealing with this kind of stuff it's so much easier to have a visual so I'm excited that he'll be sharing that and telling us more about it. Just a little housekeeping feel free to share as we're live this will be recorded so you can find the recording here on Facebook and you can also find it on my YouTube channel just Dr. Jill Carnahan YouTube that may be a day or so tells us that it will be there as well and I am delighted to introduce my colleague and esteemed friend Dr. Bob Miller. Dr. Bob Miller is trained in a naturopathic specialty and as you know I think I've had more naturopaths on my Facebook lives than medical doctors. I always joke I was born with the heart of a naturopath because I love how we delve into the same things and the solutions there are not just drugs and surgery they're really based on a much more natural approach and I always find I learned so many things from my naturopathic friends they're some of the smartest people I know so I'm delighted to introduce Bob Miller. He actually specializes in the field of genetic specific nutrition. What you're going to love about him is he's going to dive into pathways you've probably never seen before unless you're a practitioner who's studying this stuff but it's so relevant to some of the details and if you're out there listening as a patient Bob is the kind of guy that can help you find kind of hard to to pin down pieces of your puzzle and some of the pieces that might have been missing and your doctor treated you or a nutrient like why did I react to that one so as we dive into that some of that might start to make sense. He earned his traditional degree from Trinity School of Natural Health and is board certified through the ANMA and in 1983 he opened the Tree of Life practice where he served as traditional naturopath for 27 years. For the past several years he's been engaged exclusively with functional nutritional genetic variants and related research specializing in nutritional support for those with chronic Lyme disease so any of you listening out there I know that hits a lot of you and it's sad we'll briefly talk about that at the beginning but Bob I know this is epidemic in its nature and you're in Lancaster, is that right? Yes, Lancaster. Part of Lyme country. Tell me just a little bit about how you got into functional genomics and your pathway even to naturopathic medicine. Sure, well it's an interesting story. Naturopathic traditional naturopathy is my second career. I was in electronics and in the cable TV industry and in my early 30s I came down with a very severe case of ulcerative colitis that's where the colon becomes very inflamed in your bleeding. I was in the hospital for 21 days lost half my blood then I hemorrhaged. Remember vividly the night if it wasn't sure if I was going to make it till the morning and of course the recommendation was take out the colon but you know here in Lancaster County I'm a bit of a stubborn Dutchman. So I thought there's got to be other ways. So I started digging and just became fascinated and haven't turned back yet. So I was second career and of course having an electronics background we think in schematics and pathways. So when I was introduced to genomics it just made so much sense that this is just like an electrical circuit and if you follow the electrical circuit you can go back to where the dysfunction is. So that's that's a little bit of the history. Bob I love this because I had no idea we have some real parallels of our journey. First of all I was bioengineering so all this not electrical but very same idea of pathways and that and I love that's why I love talking to you and then I think you know I had Crohn's disease which is a cousin to ulcerative colitis and I had the same thing my doctor said you're going to need drugs and surgery for the rest of your life there's no other way it's incurable. We ironically have quite a similar journey don't we? Absolutely yes. That's amazing. Well I'd love to talk about what first of all let's go really basic on what is perioxine nitrate and feel free to share whenever you want your slides and get the basics of what are we talking about here and how does that relate to disease? I'm trying to share I'm getting a message at host disabled participants yeah multiple okay I think I just corrected that see if that works. There we go. Sorry. It's like the door locks on the child's room right? Your door locks are on now they're off. So again our subject today is functional genomics and peroxine nitrate and here's what we hope to learn today and that is you know what's functional genomics what's peroxine nitrate and then we're going to very quickly get into five pathways that peroxine nitrate might be made and of course you know the disclaimer you know we're not a geneticist here we're using functional medicine to help physicians as a clinical assistance tool and of course we're not giving any medical advice here. Now here's the basic premise and that is poor diet and environmental factors when combined with genetic variants in our DNA might cause an increase in toxic substances and then a decrease in critical nutrients and molecules needed for optimal health. So here's functional genomics it's no longer that model of treating or take this for that. So rather than suppressing a symptom we're focusing on either refining a potential nutrient deficiency or an excess of a toxic or harmful compound in the body and you know we think of genetics as where did I come from what diseases might I be susceptible to functional genomics isn't that we're looking at pathways and it gives you clues because genetics is just a pre-disposition as I like to say. So when you see these genetic mutations you use that as to you know where to put your detective hat on and dig deeper with the with labs and then as we compensate for those nutrient deficiencies or support the detoxification the body returns back to homeostasis. Now this is one of my favorite sayings this is a 3d chest game played underwater you know some people like to think oh what snip do I have and what do I need to take for that. I think we're going to find that that's you know way over simplified and it's not quite that simple thinking that you need methyl foley because you have mthfr sometimes does more harm than good and we have to be looking at this globally looking at it from a genetic epigenetic and cofactors because there's so many things that come into play. Now in the traditional naturopathic philosophy I had this picture drawn and it says when the house is burning down don't wash the windows and mow the lawn because way too many times I've seen this from practitioners they someone's really inflamed and they start trying to support methylation or trying to get the mitochondria going and it backfires because they're in such a state of inflammation. Now for those who are are new to this we're just going to go very briefly through genetics there are genes is what makes us human and just minor variations makes us unique. Now a gene is nothing but a section of DNA that provides instructions for protein synthesis. You know one of the things I'm amazed with I mean what a miracle we are in our creation we eat fats carbohydrates proteins we drink water we breathe air and we're exposed to sunlight and everything gets made from that I mean I just sit back and just marvel at the miracle of that how that all works well it's the DNA that makes the enzymes that makes that happen and you know many people have heard of SNPs and that stands for a single nucleotide polymorphism and that can make us a little bit unique and it's a variation in a gene and that SNP then can sometimes lower the function of that enzyme as we said enzymes take one substance turn it into another and if we have SNPs that's not optimal. Now this is inherited from mother and father each parent passes on one of their two sets of genes and this is how it works if a father has a gene variant and a mother has a gene variant there's a couple of options that can occur and that's why the same parents can have multiple children and their genetic patterns are quite different and here's another one on a homozygous genome how it gets passed on to the children so that's why sometimes parents can be carriers of disease both parents are fine the child has a problem. Now our genes are not our destiny I didn't coin this phrase but I love it and that is that genes load the gun environment pulls the trigger and I believe that we're being exposed to so many environmental factors that our parents and grandparents weren't exposed to and I believe that's why we're seeing such an increase in so many concerns so epigenetics means the addition to changes in the genetics and that's all the things that were exposed to the plastics the electromagnetic fields the genetically modified foods the growth hormones given to the animals the degassing of some of our materials that we use the lead that we used to put in our gas all of those things are having an impact on us and Bob I can just say a real quick comment gosh I just want to stop here because you know environmental toxicity mold is such a big deal for my patients and I really see this as the elephant in the room so that is the thing that's different from 10 years ago even for sure 50 years ago but I remember when I first started 1520 years ago I'd have a very simple case of Hashimoto's hypothyroid or some other autoimmune disease and it'd be fairly straightforward they get well fairly quickly and nowadays we have this set of very complex infectious load and toxic burden and so I don't want to interrupt you but I wanted to make sure that our listeners know this toxic load if you're wondering well why is it so much worse now why are so many more people getting sick from the virus this is part of the puzzle it's our environmental toxic load is overwhelming our natural immune defenses and we finally got to that tipping point haven't we Bob absolutely yes I concur completely and that's why I will talk about this later I'm having a conference for health professionals September 18 to 20 three days on mycotoxins and I'm like you when we see those people that are having challenges eight times out of 10 they're being exposed to mold and mycotoxins and actually I'm going to be showing you the enzyme that is up regulating that I think will be quite fascinating Bob I can't wait I'll be there and if you're a professional I will talk about this at the end we'll share links but stay tuned for September 18th through 20th because you'll want to be there Bob I wanted to just say to something else the mold is such a big deal I'm the mold expert I deal with mold all the time but even for me I'm always careful to go in with a blank slate with my patient and not assume there's any mold but over and over and over again we get to the end of the puzzle and realize oh my goodness this patient two has a mold exposure so thanks for saying the eight out of ten because it's so common absolutely now this slide is showing us that when we do have that mutation stepping in with compensatory things actually brings you back into balance and this is just a quick study on how riboflavin uh has an impact on the status of homocysteine lowering effect of folate in relation to the mthfr genotype all right to answer your question peroxinitrite this is just one of the many things that puts the house on fire so to speak now what it does there's a very important molecule called nitric oxide and we need that for circulation we'll talk about that and then a rather nasty free radical called superoxide and this has an important role in chronic inflammation immunity and aging and I'll show you how mycotoxins actually stimulate the production of peroxinitrite it's hypothesized to play a key role in various degenerative states and several analysis suggest that selenoproteins particularly the selenium dependent enzyme glutathione peroxidase they have an important role in the detoxification and in illumination I find it interesting uh the symbol for peroxinitrite is oh no love it yes uh broad spectrum antioxidants uh vitamin e melatonin they be a part in preventing the formation of peroxinitrite uh peroxinitrite formation rises 100 fold for each 10 fold increase in superoxide and nitric oxide production so what we're saying here is that superoxide generation is a potential mechanism that disrupts nitric oxide and we'll be talking about that and I've been you know talking about superoxide for probably 10 years probably in the last two to three months that I've just looked at it anew and said this is likely more significant than uh when then we realize right well it's in the sense that the theory that I've been hearing with why the antioxidants like zinc and vitamin c and um even minerals can be so powerful with viral infections is that this anti this free radical state is part of the thing that allows pathogens to proliferate absolutely yeah absolutely I mean that goes back to the traditional naturopathic philosophy 75 to 100 years ago when you know traditional folks at these people are quacks that should be in jail uh but now you know the the science is coming out and proving it to be true we're right all along yeah so nitric oxide I'm sure people have heard of it it's in the cardiovascular and nervous system it has a very short half-life and this actually won the Nobel Prize all the way back in uh 1998 nitric oxide is critical for blood pressure preventing thrombosis preventing leukocyte adhesion to vessel walls increases the flow of nutrients to critical organs and improves the efficiency of waste removal now we're going to talk about superoxide inside the cells sometimes an electron flies off combines with oxygen and that makes what's called superoxide and this superoxide has been hypothesized to be a potent key player in the aging process all right now we're going to start to geek out here so hang on to your hat here we go okay I'm going to get my drawing tool here and uh we're just going to have a great time so one of the things that we need is this nitric oxide that we spoke about and the nitric oxide is down here vasodilator and electron donor now it's quite a complex process to get there we need a substance called bh4 tetrahydroopton now things can go wrong here aluminum can suppress that with or something called the urea cycle in the kidneys that clears ammonia and these are the genes involved in that and if we have any genetic mutations or anything else that goes on that excess ammonia will also use bh4 to be cleared that's why ammonia levels are so important now we're going to talk later about nadph my favorite molecule me too yes nadph combines with bh4 oxygen and something called arginine then the enzyme NOS takes it all and makes nitric oxide unless something goes wrong after bh4 is used it turns into bh2 we can have genetic mutations in these enzymes that don't allow it to come back we're going to talk later about the nadph steel where nadph is used to actually make free radicals you'll notice there's also heme right here heme is a co-factor and there's eight steps that we need to make that heme and look who we have here glyphosate glyphosate can impact the glycine that's needed for this heme cycle wow these are people that often get hangry they're they get very upset and angry if they don't have food on a regular basis so what happens if something goes wrong here oops we make superoxide that combines with that very important nitric oxide for oh no peroxanitrite and guess what that does it further suppresses bh4 and this feedback loop just keeps going and that's why sometimes people will take l arginine thinking that oh i'm going to build my nitric oxide levels and all they do is hurt and get some viral infections so bob i want to just make some a few things things that are a ha's for me clear because i bet your listeners are saying the same thing first of all aluminum sources of aluminum super common right um i can think of obviously cooking in tinfoil aluminum um antiperspirants which is why we should only be wearing deodorants um do you know any other i mean vaccines nowadays they contain a lot of aluminum and again i am not your anti vaccine person but we have to think about load and all this i'm actually checking every patient right now with aluminum levels you would not believe the load i'm finding of aluminum so that's a really big deal ammonia um i know the gut can produce ammonia um some sorts of dysbiosis in the gut especially bacterial and parasitic um any other sources of common for ammonia in patients that you know of well sometimes eating too much protein not chewing well and plus genetic mutations yes in the urea cycle okay and then glyphosate clearly non-organic food if you're not eating organic you're going to get that on and now we know even organic california wines have traces of glyphosate so you can't be too careful with that absolutely and i forgot to point out lead lead inhibits nos and of course we had lead paint many years ago led our gasoline so if you have aluminum and lead your ability to make nitric oxide is compromised this is where people get cold hands and feet renaughts high blood pressure and we'll show later how important nitric oxide is and just arginine is not the solution i just want to reiterate that there's a way bigger pathway here that you're going to explain to us absolutely so here's the potential you know makes i'm not going to read them those are all the things that could go wrong that make it difficult uh the lead aluminum the glyphosate and here's again as we can support function okay sami acid etymothionine and methyl folate or royal jelly can actually help you make more bh4 yucca larch citrulline and alorethine can help that urea cycle interestingly which hazel and rosemary will scavenge peroxanitrite sod will help you neutralize that superoxide so you don't chew it up pomegranate green coffee bean garlic and hawthorn all support the nos enzyme so there's a lot that can go wrong in there and that's why when we do when we train our doctors on how to do this uh looking at this is one of the first things we look at because again cold hands and feet uh there it goes veins early uh hemorrhoids all of those things can be related to that nos uncoupling now i'm going to move over to iron we all know irons critical i mean we don't have iron we don't carry our oxygen life doesn't exist however something can go wrong so let's look here so there are genetic mutations that people have very high in english irish and ashkenazi jewish that caused them to over absorb iron and that was actually adaptive the irish during the potato famines if they absorbed more iron they actually did better but today we don't have famine and we're putting a lot of iron in foods so what can go wrong here again we talked about the body will make superoxide sometimes on its own we need superoxide dismutase to turn that into hydrogen peroxide however then we need something called catalase to turn that into water and oxygen we need glutathione peroxidase to turn it into water and we need triadoxin to turn it into water now glutathione and triadoxin they donate electrons and you'll hear this a lot look who's needed to keep recharging in adph is this where hydrogen can be helpful because that's a donor for either the hydrogen tabs or the inhaled would that be in this absolutely yeah right here we are so what happens is when that iron is in excess or it doesn't even have to be in excess combines with hydrogen peroxide to make what's called a hydroxyl radical which damages protein carbohydrates and DNA so here's where your hydrogen water can come in and neutralize that hydroxyl radical but we need an adph glutathione triadoxin catalase a lot can go wrong in here this is the most common thing I see and actually it's what won me the research award in 2016 at the Helsinki iLADS meeting showing that those with chronic Lyme were five times more likely to have one of the genes that would cause them to absorb more iron now one of the ironies is many times people say well I can't be absorbing more iron because I've always been told I'm anemic well of course if this is happening if this excess iron is coming down here you're making more hydroxyl radicals and then if a well-meaning practitioner says oh I'm going to make you feel better by giving you iron if this is occurring you'll actually make the person worse so what we have to do is get these pathways going then you have all the iron that you need this is called the Fenton reaction named after Dr. Fenton who discovered this in 1895 now what continues to happen here so this OH- will stimulate INOS which is another form of nitric oxide combined with again to make peroxynitrite now on this drawing we showed how this also leads to something called carbonate radical CO3 which oxidizes your DNA this is actually DNA damage that can occur so this is a very dangerous process and that's why as we said hydrogen water those tablets or the air that you breathe or hydrogen machines can be one of the most important things if someone said to me Bob you can only take one thing is the new law that you can only take one thing call it I'd have to say hydrogen water Bob I couldn't agree more if people forget they're cheap they're easy now the inhaling machines which I have in my office I use when I'm doing charts three two three days a week I use it I love it I feel so good that's a five thousand dollar machine not everybody can get that but everybody can afford the hydrogen tabs so I agree I highly recommend those as a an adjuvant therapy and it easily absolutely I was just using my hydrogen machine before the call just to make sure my brain was I love it all right I'm not going to read these but these are all the genetic mutations that can cause this to go arrive again glyphosate hydrogen water skull cap clove alphalipoic acid can support the proper use of iron SOD catalase we'll talk about this later nicotavide mononucleotide supports the production of NADPH and also copper is needed to make ceruloplasm and there's also many times mutations in the beta carotene to vitamin A and we need vitamin A and of course selenium for your glutathione peroxidase now the beauty of looking at the genomics is you can see where you need the support now EMF there's just more and more information coming out about this and I think we're going to look back someday and say oops because good intentions you know I often give the analogy you know think of asbestos what a wonderful thing because the houses didn't burn down and people didn't die but then there's that unintended consequence you know we thought lead would make our world better by making our paint better and making our gasoline more effective oops I'm afraid we're on that same path now what happens is we have membranes that store electrical potential across their membrane in the form of an iron gradient and this stores the electrical potential well what happens when we're exposed to EMF that electrical potential goes up this is a new chart we literally made days ago so here's calcium and there's a gene called CACNA1C and it's responsible for the calcium coming in now once it gets in it turns into calcium calmodulin now I've never seen a genetic mutation more accurate than this one mutations on this I've never seen anybody who didn't have it who didn't tell me that they're sensitive EMF they're more impacted by EMF and this of course creates inflammation on its own but since we're talking about the the peroxanitrite what does the EMF do creates the nitric oxide the superoxide from the EMF and makes the peroxanitrite yet another method to make inflammation inside the cell one of the things I and truly question I don't say this is a fact but Bob Navio has done some great work on the cell danger response and I have to wonder if this is not a factor involved in the cell danger response when the body's just kind of in that half shut down trying to preserve itself because inside the cell all of this is is going on so that's why you know making sure you're not sitting next to your router all day not carrying your cell phone on your body use speaker phone or earbuds not the type that you put the transmitters in your head but like those at least wired or or air ones and I often tell people that who have this is their severe problem you need to make your house very dumb do not have a smart home yes I couldn't agree more and I would say if you if you are sensitive you need to get wired internet of course I still have Wi-Fi I'm actually not as sensitive I probably should a lot of my friends just recently said Jill you know better you need to get wired so I'm probably going to be doing that but right now I have a router cover that protects me and I had a building biologist come to my condo here and check everything out and there's a meter they'll put on your body to see the voltage and then they'll check as they turn switches and check electricity my measured body meter voltage was over 3000 with the on the bed I just laid my bedroom on my bed with the normal no special lights nothing special on when I turn the master bedroom switch off it went to less than 200 that was a shock to me which means I have an appointment to get a master switch with a remote so that at night I can turn off the electricity just in my bedroom by remote and I would highly recommend if you have the resources to get a building biologist to come check your home as well when you say there's a shock to you no pun intended right exactly and Bob the funny thing was I would tell you I'm not really emf sensitive I mean I do wear bioelectric shields I protect myself I do a lot of things but I don't feel physically that ill from it like on the spot however as soon as she turned the breaker my heart stopped fluttering and went still and I didn't even notice it it wasn't like I had tech a card here or anything but I felt the physical sensation of the chain so it's very real absolutely and these teenagers who keep their cell phone under their pillow to hear if a cell by the brain there's glucose metabolism studies that show the the length of distance from your brain absolutely affects brain glucose metabolism and it's exponentially so if you have your phone right next to your head it's a very very bad situation yes I recommend getting like a battery powered alarm clock you know rather than using your cell phone people tell me yes right by my head because I use it in my alarm I think there's going to be serious unintended consequences from that so potential genomics the CACNA1C that we talked about making sure you have enough superoxide dismutase NOS is working okay and you have enough glutathione of course the epigenetics is the the EMF I'll never forget I heard a lecture from Dr. Sinatra and he said if you come to our house we have princess phones on the wall I love it so magnesium witch hazel melatonin rosemary that we talked about and superoxide dismutase and I think you know so many people are using you know they have like Netflix and they stream it to their television I think it's a good idea to have your TV wired rather than streaming it because you're exposed to so much EMF when you do that it just adds up so anything that you can do to decrease and I noticed rosemary is coming up over and over and over again I'm a 20 year 19 year breast cancer survivor that's a big one for breast cancer and there's no doubt there's a connection to this pathway because of DNA damaging effects right oh absolutely because it's taking care of that peroxide nitride now glutathione most people know about this major antioxidant it neutralizes superoxide it neutralizes hydroxyl radicals it's one of the powerhouses of the cell it regenerates vitamin c and e it's involved with detoxification aging and degeneration as we age our glutathione levels go down so we tend to think of glutathione cool the more the better and I'm sure dr jill have you ever given someone glutathione and they had a negative response to it oh yes bob and that's a that's my story and I just had a colleague just talked to us that I was like that for two years so tell us more because I'm one of those people yes well here's what happens glutathione and we just for up here we just show how it's made for fun it's you know anacetyl cysteine up here would be your glutamate your glycine and then the gss enzyme makes your reduced glutathione and then glutathione through glutathione as transferase does what's called phase two glutathione conjugation where we take out toxins and we put them in the stool or the urine and then also glutathione peroxidase neutralizes free radicals so we tend to think the more the better however some people take glutathione and they're like that is the most wonderful thing i've ever had and then other people are like i can't take that i feel horrible when i take that so let's look what happens glutathione does its job donates an electron and it becomes gssg or oxidized glutathione look what oxidized glutathione does you've heard this before combines with the oxygen to make superoxide then choose up more of your nitric oxide to make peroxynitrite oh no and then we have to use some glutathione to deal with that here's why i think nadph is so critical and not enough people are looking at it nadph donates an electron to the oxidized glutathione to take it back to the reduced that and again these are just some of the things that'll make the glutathione i'm sorry the nadph and i'll be talking later about the nadph steel so when you take glutathione and it doesn't recycle you have a problem isn't that fascinating that makes so much sense um i find that when we do give people the donors to make nadph it does help with these pathways so absolutely yeah that's why i believe that we have to learn if somebody has an nadph deficiency and support this before we start putting this in i was just going to say that first piece is often not what you think of like you said with your analogy the house and the fire and what to do first i love that because many practitioners are just this um protocolized thing where it's glutathione and liver support and detox and patients aren't ready for that if they don't have the nutrients in place and with your genetic testing people you can tell exactly what things people might need more of beforehand and the most common thing i see and those that are suffering the most they've got either nas uncoupling or fentanyl reaction along with nadph deficiency most common thing i see so we need to look at some of the enzymes that are involved in making nadph i didn't mention in that chart but there's something called nerf two and keep one that controls all the glutathione and nadph genes gsr i should mention that that is the enzyme that uses nadph so even if you have enough nadph and gsr is not working this isn't occurring double whammy is nadph deficiency and gsr problems so glyphosate again can be a problem ticket to mind mononucleotide polyarco helps nadh to nad plus grape seed extract helps the quinolidic acid move down the pathway and then a few things for nerf two milk this old broccoli seed extract to support nerf two but again if you support nerf two too quickly it can actually put people into inflammation so again sometimes it's like nerf two yes it's so important people support it and they get worse all right now this is probably the most important thing i'm going to talk about nox nadph oxidase my favorite subject and i've been talking about this for two years it's the only enzyme that its sole purpose is to make superoxide and hydrogen peroxide now we tend to think well why would it do that well again the wisdom that god put in the body is absolutely astonishing so when we're hit with a bacteria or some other pathogen the body says oh we got a problem here we need to create some superoxide hydrogen peroxide stimulates a mass cell stimulates some cytokines make some histamine and let's go in for the kill if we didn't have that we die of infection in animal studies where they take it out so this is an important process i give the analogy it's kind of like the military you want a military that protects you but you don't want a military that's turning the guns on the citizens and one of the areas that we're researching is our epigenetic factors stimulating this nox enzyme to start shooting when there isn't an enemy and that's one of the areas that we continue to uh to research now we're really going to bend your mind with this chart and what i'm going to do is i'm going to pull this one over where we can look at it just a little more closely so nox enzyme it's needed to create this cytokine storm and mass cells when when we are faced with uh with an outside invader however histamine will make it go oxalates will stimulate it excess iron will stimulate it glutamate will stimulate it smoking or particulates will stimulate it aldosterone that i'm going to speak about in a minute stimulates it homocysteine dopamine sulfite and something called mTOR stimulates it so when it gets stimulated it gets oxygen from iron and a molecule from nad or a electron from nadph now keep in mind we just learned we need nadph for nitric oxide we need nadph for glutathione we need nadph for thryodoxin so that's why I coined the phrase the nadph steel this nadph is being used excessively to create this storm so then it creates the mass cells and here's mycotoxins here's Lyme disease emf xenobotics the mass cells will then create cytokines stimulate these interleukins tumor necrosis factors and histamine all good things when we're fighting a battle and we have somebody to take care of to take out when it's running amok we have a problem now this is some of the latest research that i think is very exciting we have something in the body called renin and that stimulates angiotensin one the ace enzyme makes angiotensin two that stimulates the aldosterone that then stimulates the dox enzyme and of course we know this is what's behind hypertension there's an enzyme called h-mox that calms this down when people have mutations in h-mox they can't calm this down now there's an enzyme called ace two that takes these pro-inflammatory vasoconstrictive molecules and turns them into angiotensin 1-7 which is vasodilative in anti-inflammatory as a side note COVID-19 comes in using ace two i was gonna say i know where you're going with this because a lot of the side effects we see are from that vasoconstriction correct absolutely so this angiotensin two then stimulates interleukin six which is behind the cytokine storm yes interleukin six stimulates NOx and it goes around but here's what's really exciting just presented this to my doctors last night in a webinar histamine mast cells and peroxanitrite remember whenever you have superoxide you're going to get peroxanitrite hold onto your hat stimulate renin wow and here we have a positive loop that just feeds upon itself high glucose peroxanitrite histamine conflicting information on dopamine but also testosterone stimulate the renin you know this might be one of the mechanisms behind the cytokine storm and so for example if something kicks this off like if a child with you know gets a strep infection and then goes pans pandas or as you said earlier we're not anti-vaxxers but if you get aluminum and the aluminum stimulates this this could be one of the mechanisms that causes that to feed upon itself now what's interesting is that nitric oxide in oxytocin calm down NOx and mast cells and if your nitric oxides being destroyed we don't have it and of course oxytocin the love hormone so go hug somebody or at least to hold your cat or your dog okay we've had social isolation for two months and starting to come back but we're not frequently hugging one another hugging is one of the main mechanisms that's not breastfeeding or sexual that increases oxytocin i've said for months i've said yes i agree with what's happening we need to take precautions but we're not thinking about the fact that social isolation is a huge risk factor for immune dysfunction and now you're telling me it's a huge risk factor because you have less oxytocin production for the blocking of this enzyme absolutely so i'm really excited about this pathway and and clearly there's way too many genes to go in here but these are all the genetic mutations that could contribute to that here's all the epigenetics that could combine to it and then luteolin pea baswellia can calm down the mast cells nettle leaf quercetin can support the histamine response methylation supportive elevated homocysteine and as we said mold remediation so important air purifiers superoxide dismutase we spoke about those before that can support the uh that can support the NOS enzyme so i believe this might be behind why we're seeing such a rise in autism dr. Thea Hardee's from Tufts University believes that mast cells are behind stimulating the hypothalamus that may not be the whole answer but there's the potential that that could be an issue and needs to be uh to be researched so i think for anyone who's doing functional medicine trying to determine if any of these factors is up regulating this is uh critical and now you can see why i call it the 3d chess game. Bob that is a key go back one more time to that slide i want to hear your your contact we have a minute and this is so key i just want to hone in on this i'm having about 101 ahas now as i think about this i think about what we just went through with pandemic and have ongoing and the types of risk people have whether it's predisposition diabetes heart disease has to do with a lot of these pathways and the same cytokine pathway is active with lipopolysaccharide endotoxemia which is a long technical word for leaky gut when you have bacterial coatings leaking into the immune system they stimulate the same isle six pathway as well and i feel like a lot of the risk factors we're seeing with heart disease diabetes um age they're more likely to have some of these things i think already primed and then you just gave us a list on that other slide of uh the allergies and mycotoxins and Lyme disease and these are all likely to lead to more inflammatory states more risk of infection and probably more risk of the virus being an issue. Absolutely and that's why sometimes bodybuilders are those who are trying their best to keep their testosterone and stimulate their mTOR maybe at the highest risk right now. Wow. Yes now one of the things we just heard was that there was a drug that was discovered in England that seems to get people out of the cytokine storm. We immediately researched this and what we found is it inhibits the NOx enzyme. Wow. Yes. Wow. I think you sent me that study. I remember us talking back and forth um and if not I would love to see the research that sounds so familiar because of pereoxynitrate and the cytokine storm because really this is such kind of like the cell danger response it's almost like we're all looking in our areas of the same thing and describing it but it all comes together with such cohesiveness because it makes sense and as we went in the very beginning to pull it back together for a practical takeaway otherwise this is overwhelming. First of all if you can get with the functionalists and doctors especially one that's been trained by Bob they can help you walk through these pathways and I know Bob does consults himself and but mainly do you mostly teach doctors Bob do you do? Yeah mostly we we have online certifications for the doctors and I do a lot of one-on-ones with doctors where they'll they're like Bob I need help with this and I'll you know walk them through it to give them the the guidance they need and I can just say if someone is a doctor and they're interested in the software there's the website dnsupplementation.com Yvonne Lucasi is the executive director she can help and if someone wants to contact our office there we are Tree of Life Health there's our phone number and our and our website and then also there'll be links there to our conference September 18 to 20 and I have an online certification course for doctors that walks them through like we have probably around 30 hours of instruction that step by step takes them through that NOS uncoupling the glutathione the the the mass cell activation so if doctors want to learn this we have a resource for them to to learn this. Excellent and Bob I'm going to share this with my practitioner list and I'm going to ask you guys if you're listening if you have a doctor you know you know I'm on Facebook or another medical provider or someone who is in the functional medicine realm please share this information share this lecture with them I think everybody should get to know Bob Miller he is one of the brightest stars out there and what I love about Bob is you can tell he's brilliant I love talking pathways but even more than that he's got a really great heart he really cares about people he cares about finding solutions and I just every single time we talk Bob I learned something new I am so grateful for minds like yours and hearts like yours that are out there just continuing to do the science because this is the kind of thing that really pulls it together and as we both know this is the only real thing that's going to change our system a drug itself might be a potential solution but a drug is not going to help the hundred percent of the population because of these genetic variations so we have to have solutions that are more personalized. Absolutely and let me also say I think the world is very fortunate that you're out there leading the way and helping educate so many doctors I think when the books on functional medicine will be written there'll be a large part talking about Dr. Carnahan and you know you have a beautiful heart as well that you want to help people get well and so the utmost respect and admiration for you. Thank you so much Bob this has been a real treat please be sure and share I'm going to include in the links the things that you saw on the slide as well so if you missed it you can also watch this again but I'll be sure and include that all thank you