 It's consisting of five probiotic bacteria, basically a consortium of bacteria that is designed to address the root cause of the bad breath as opposed to the mints and gums and mouth washes of the world that just mask the bad breath. Boom, what's up everyone? Welcome to Simulation. We are following up on IndieBio demo day. We now have Oralta in the studio. I'm really excited to talk to Kishore and Patrick the co-founders. What's up guys? Remember to read that. Good, how are you doing? Good, Alan. Thanks for coming on to the show. Thanks for having us. I really appreciate it. So okay, this is really important stuff. I'm really excited because it's actually probably one of the most relatable, applicable companies right there in the daily use of people's lives. So Oralta, and we'll get a little bit into your histories and what got you here. Oralta, a fresh breath probiotic. So give us a quick taste of the like fresh breath probiotics and then we'll go to history and then we'll get to the more nuance later. But give us that little taste. Yeah, so the actual taste off the tablet is a slight minty flavor. It's consisting of five probiotic bacteria, basically a consortium of bacteria that is designed to address the root cause of the bad breath, as opposed to the mints and gums and mouthwashers of the world that just mask the bad breath. Okay, so this, what you just said there, I want to unpack later. Getting to the roots instead of masking. We'll get to that later. So that's the quick bit on Oralta. Now tell us about you guys. So how do human beings, Indian, German, how do you guys figure out, I'm going to go into the U.S. I'm going to pursue entrepreneurship. I'm going to do biotech stuff. I'm going to do breath stuff. How did that story unfold? It's a long story from my side because I started off as a computer science engineer in India. And I did my master's in biobachelors in India. And I flew into the United States, to the University of Iowa, Go-Hawks, to do my PhD in biomedical informatics. In India, I had a thing where like after your 10th grade, you can either choose only math, physics or chemistry or biology, physics or chemistry. And the opportunities for math, physics and chemistry were much more than biology, physics and chemistry. But I loved math and biology and I could not pursue it. So I had to take math, physics and chemistry. And I had this wired in me, like I always wanted to do biology. And after I finished my bachelor's in computer science and master's in computer science, then I got this, I read this book called Genome, where they talked about how there are new opportunities opening up in the field of biology for computer scientists, where they need a lot of analysts, statisticians, computer programmers to understand the genome projects that are happening currently at various research universities in the United States. So I applied to a bioinformatics program, where I could apply my skills as a computer scientist and apply it to biology to understand various health and disease concerns of citizens. So that's what helped me to apply to the United States. I did my PhD there. And in my PhD, I mostly did cancer genetics and cancer bioinformatics and some basic bioinformatics. And then I got my first graduated from University of Iowa, got my first job again in Pioneer Hybrid, which is a plant genetics company. And I was doing plant genetics there. So I made a switch from cancer genetics to plant genetics or plant bioinformatics. And then I moved to bear crop science. And that's where my introduction to microbial bioinformatics happened. And that's where I met Patrick too. And Patrick is an excellent scientist. And we both had this entrepreneurial ambitions. And we came up with this idea, but Patrick will talk a little bit about how we came up with the actual idea. But Patrick is my colleague and a very good friend when we were in bear crop science. Tell us about the journey as well. Yeah. So my background, I was born in Germany. I studied there, bachelor, master PhD. And as many know, Germany has not the best weather in the world. So it's pretty rainy, especially the university I was at. So that's, it's, I always say it's partially the reason I wanted to go to a really nice warm place after finishing my PhD. And so indeed, I came to California to do my postdoc here in the Bay Area. But also already in Germany, doing my studies actually was the co-founder of a startup. And as such, you know, about San Francisco being the mecca of startups. So that was another big, big reason to actually move here. What was that startup they were doing? So this was in the browser game space at the time, you know, Facebook browser games were really big. It probably still is. Yeah. So that was it was in this realm. Yeah. So then here after my postdoc, I joined bear crop science, where then eventually met Kishore. And basically, all my background, my studies were all focused on industrial microorganisms. So it's can be tell us about that. You're both doing that industrial microorganisms. Right. Well, we were, we were basically doing soil microbiome studies. So we were trying, like the way we came up with this idea is we were working in plant microbiomes, where we were identifying bacteria that make the plants grow better or help them fight fungal diseases. So we realized that, you know, Patrick has a patent on that and I have some coming up. But we realized, okay, if this works for the plants, it should work for humans as well. And, you know, we realized that we could rebalance the oral bacteria from a disease to a healthy state by introducing healthy bacteria. So we were doing the same thing for the plants. We thought that's translatable to humans. I mean, they're already working on God, but nobody's focusing on the oral health. Yes. And oral health is a serious concern. And it's part of the GI tract. Yeah. Yeah. It's the opening, right? Yes, the opening. Exactly. Interesting. But I just wanted to say along the way, so it started with what adding healthy bacteria to plant eco soil ecosystems. And now it's like, how can that be applied to humans? Yeah. So maybe two more words before that. So the rhizosphere, which is really the microbiome of the plant. The what? The rhizosphere. Rhizosphere is the soil. That's like the microbiome of the plant. Exactly. The first time I've ever heard that analogy. That's interesting. So the rhizosphere is a much more complex environment than the mouth, actually. So there are thousands, over thousands of microbes known to exist around the rhizosphere. The human microbiome has on average only like 700 different species at each individual. Like overall, there are also a few thousands. In the mouth. Yeah. And so we really thought, basically, we tackled a more difficult problem in the past when we were working at the rhizosphere. So now translating all this knowledge and the algorithms we have developed in the past to the oral microbiome would make a lot of sense and actually allow us to be even more impactful with that because it is a simpler, but still very complex field. So then what was the moment for you two when you were there doing all this, the rhizosphere of the microbiome of plants, and you were learning about this, making your own algorithms, figuring this out, and then how did you guys go? Let's do this. How did that happen? Okay. All right. So myself, sometimes plaque was with cavities, whereas key shore has like perfect oral health. So he wouldn't even have to brush, he does it, but he wouldn't have to, he wouldn't get cavities. And so the reason is that his oral microbiome is just a very balanced and healthy one, whereas mine seem to be suboptimal. What does a healthy versus an imbalanced oral microbiome look like? Is that what do you call it an oral biome? Oral microbiome. So it is not one specific target state where you have a certain number of microbes. There's basically an infinite number of states that could exist. But what the disease states usually have in common is that there's an overabundance of certain detrimental bacteria. And do we know which ones that is? There are certain strains known. There's streptococcus mutants, for example, which is associated with tooth decay, but there are various others. And this field is not exhaustively known actually. So there's still research going on as we speak. As we take samples of our poop, may we also take samples of our oral microbiome to figure that out at the same time? It seems like a good idea. Exactly. And it's obviously much more accessible and easier for people to donate the samples to this course. I will ask you that later. I will ask you if you are interested in taking oral as well. Okay. So then the moment though, when you were like, aha, let's you were talking about the oral health differences between you two. Yeah, right. So I think it was one day I came actually back from a dentist visit and was just a little frustrated about hearing that there might be another cavity here and there, although, you know, I floss and brush and do everything you possibly can do. And, you know, we are just sitting over a beer and thought, well, you know, we do this as a day job to figure out what are the healthy microbes for plants. And we put them on the seeds and they grow strong and vigorous and protected. So why are we not doing this for the oral microbiome too? In essence, it was really like self-interest at first. How can I improve my own situation that may be of my family and friends? And then very soon this idea grew much bigger because, you know, most people don't know it, but there are 95 percent of Americans who suffer from some sort of oral condition, which is a staggering number. And what would out of the 95 percent that suffer some oral condition, what are the top oral conditions that people usually suffer from? Yeah, so the top oral conditions are tooth decay and gum disease and bad breath. Okay, now, okay, I think people are familiar with bad breath, maybe not so much the causes, but then the gum disease, people kind of can see the gum lining receding over time. And then, yeah. Gum lining receding, I think. Go ahead. Gum line receding, I don't think has got to do with, I mean, we're not sure, but you have gum disease and that also has some implications in bad breath. But I would say the, like the overarching that there's three conditions, bad breath, tooth decay and gum disease. And then again, within gum disease, there is gingivitis, periodontitis, and there's like a bunch of things. And for each thing, there is a different microbiome that causes these conditions, right? Like, for example, Patrick was alluding to their streptococcus mutants that causes caries or tooth decay, but everybody has streptococcus mutants. But there are certain conditions and certain presence of other bacteria that makes it pathogenic or that causes all sorts of, it makes it pathogenic and causes other disease conditions around in the mouth. So we have to identify what kind of consortia of bacteria are causing health and disease. And okay, so yeah, that's a key there. Okay, what consortium bacteria caused the tooth decay and gum disease, bad breath? And then what are the ones that cause good health? Good health. And so then what have been your tools of analysis for that? So Patrick can talk about the tools. So besides, I want to start, besides Kishore and myself, we have another team of co-founders, so there are four of us in total. David Drake and Jeffrey Bannas, they are both long-term professors at the University of Iowa College of Dentistry. Both individually have over 30 years of experience in analyzing the oral microbiology of humans. So with their help, we were able to dig really deep into the literature and understand what is known, and which of the known microbes would act well together. This is when we started experimenting and then eventually came up with a proprietary solution of five strains that really work synergistically very effectively to fight bad breath. And the five proprietary strains that you came up with to fight bad breath, that these fight bad breath and gum disease and tooth decay or just the bad breath? So this is our first product, which we will talk about later, I guess, is targeted for bad breath. So this is specifically designed for bad breath. What does the tongue look like at a microscopic level? It's like little bristles, right? Like little things next to each other like this? So it is a surface riddled with crevices. It's a very rough surface. This is also why, for example, if you take mouthwashers, you will never be able to remove all bacteria from your tongue. They are always hiding deep down in the crevices and they will grow back from there, especially with mouthwashers. That can be a problem because detrimental strains tend to grow back faster than beneficial ones. And then you are usually often left off worse than you were before. It's like there is a constant state of war in the mouth. So there is different, think of all these bacteria as different tribes and they're just fighting for a competition in the mouth. Like they have their own weapons, they have their own antibiotics to suppress the other ones. So sometimes they work together, they make alliances with other species of bacteria, work together for the health of the mouth, but also there will be other alliances where they work together for the diseased state of the mouth. So they become pathogenic. So they recruit other species, both for disease and health. So it's, you can think of the mouth as like a war zone, where there's this good and bad guys constantly at war and they make alliances and they have different set of weaponry. Some has a better antibiotic, some are like voracious at eating up all the resources. This literally sounds like the evolution of humanity. Yeah, exactly. And that's constantly happening in your mouth, in the gut, in the skin everywhere. So even in the house too, like for example, if you close all your windows and there is the reason why I think our elders say open your windows is to let the new bacteria come in so that there's not one kind of few types of bacteria that is overtaking the so you're maintaining a healthy balance of the bacteria in everywhere, like in the mouth. That's why you brush your teeth. Fresh oxygen too. Exactly. Yeah. Yeah, with the air comes the bacteria. Yeah. Okay, you were just going somewhere though, that's why you were saying that's why you brush your teeth because you open up new space for new bacteria. Yeah, when you're brushing the teeth, you are removing the whatever is on the upper surface of the teeth or the tongue and making space for others. Exactly. So you're not letting one particular type or a few particular types just outgrow and outgrow the others and become pathogenic. So that's like the physical effect. I mean like physically you're removing them. So if you use our probiotic, what happens is their probiotics, their natural environment is the mouth. So they actually proliferate faster and make sure that the other ones are not coming in and occupying the oral space. How did you pick the five or six strains? Like Patrick said, the literature, the literature. We also have two professors co-founders who are who have over 30 years of experience in the space. So they helped us with this formulation. And the formulation, now do you list them here because that's the IP, right? So they are listed, they are just not listed in the exact ratios we designed them to be in the tablet. Proprietary probiotic blend, right? Exactly. Streptococcus salivarius. That's correct. M18. Streptococcus salivarius K12. Lactococcus lactis. Lactobacillus Rirotiri and lactobacillus salivaris. And you see that three of those have salivarius in it. So their natural environment is the saliva. So they found, they first found them in the saliva. So they are, so for example, I'm an Indian, I thrive better in India, right? So their natural environment is the saliva. So they grow better than the others, the pathogenic ones and they are better at using up the resources in the mouth, depriving the other pathogenic bacteria from getting any resources or foothold in the mouth. Interesting. And then the, this is 103 milligrams of the probiotic blend. And then what percentage of the entire probiotic supplement is that 103 milligrams? Do we know? How much is each one? So are you asking about the weight of a single tablet? Yeah, like what percentage of the actual tablet is just the probiotic blend? And then what percentage of it is xylitol, microcrystalline cellulose? Actually, at the top of my head, I don't know. I have the data of course, but of course, yeah, I don't know. See that this is, this is my job is to, is to ask these questions. And now you're like, I'm going to know that. So interesting. Now, can you, so the ones that don't say salivarius, salivarius, lactus, praetary, right? What are, what are those? So the, the naming oftentimes suggests the origin, not always. So these, all these strains are what's in the industry called grass. So that means generally, generally recognized as safe. So they all originate from, you know, healthy human subjects. Not all of them have been named salivarius because similar strains have been found in other environments before and then you name them after the next closest species or strain. And that's why the names are not necessarily all ending in salivarius. And then how do you know that having, how many times have you now tested these five versus adding a six to one versus taking one out? Yeah. So, so there were several iterations through which we've, we've went. So not all, not all probiotics, you know, synergize very well together. Some might even antagonize themselves. So we found that this, this combination is the most efficacious. Let, and that might also be true for different populations of people, as in my oral microbiome is different someone across the world, right? So Oralta might have to come in different, for different cultures, different people, is that possible? Yeah. So you're talking basically, you're sketching now on a topic that's really interesting. So the microbiome of every individual is basically like a fingerprint. 5% different, right? It's like a fingerprint. Basically, it's really unique to you. But the difference with the fingerprint is that it's really, it's staying for the life of you, for your lifetime. The microbiome is actually constantly also evolving and changing. So if you eat one day, if you drink hot tea, you sample before and after drinking hot tea, you will probably get different results. Even worse, if you take an antibiotic because of some other condition, after you're taking the antibiotic, you rapidly change the microbiome in your mouth and your gut, wherever it comes in contact with. And other things are impacting your microbiome, like obviously your eating habits, your oral hygiene routines. Yes, even if you have things like you open, you sleep with an open mouth, it changes. That's an interesting one. Like various things, if you do a lot of sport exercises, how much water you drink, if you're smoking, alcoholic, all these things rapidly impact the microbiome. Yeah, that's like a dozen variables right there that are, right? Which, you know, which kind of then the next question would be, oh, so how do you know this works for most people? Yes. And the answer is, this was designed specifically to target the strains that are known to cause bad breath. So if you have bad breath, most likely you contain strains, you have strains that these strains that we provide target or fight. So regardless of what kind of condition you have, there's a high probability that this consortium of bacteria is going to be efficacious against your condition. How does one measure if they have bad breath? Because when everyone wakes up in the morning, don't we all have bad breath? Yeah, so that there are various reasons for bad breath. And we also want to distinguish clearly bad breath from eating food that causes bad breath because of the food being smoked. So we're not, we're not addressing that. This is like a temporary condition. Garlic, if you eat garlic, you smell like garlic. So we're not going to do anything about that. But we're really focusing on the chronic halitosis so that people have constantly and also when they wake up in the morning. So one other thing to touch up on what you said is regards to like how the dynamic, the microbiome is, but for each disease condition, we also believe there is a core microbiome in the sense like there is certain set of consortium bacteria that definitely occur in a certain disease condition. So if we address and target those bacteria, we would be with our own consortium bacteria, we would be able to do that. Interesting. But for the rest, that's the core microbiome. That's the core consortium bacteria that cause that particular condition. So if we can target them, we will be able to mitigate that condition. But there will be a lot of other species of bacteria floating around in the mouth. I've got nothing to do with the condition. So back to the war analogy, are you sending soldiers in to combat the bad? Is that kind of the... Yeah, we're sending the soldiers in, but also that's their home. So we're sending the soldiers in to their own country. To their own country. And then what they're doing is they're kind of taking out the bad actors in their country. Okay. The ones that cause the gum disease, tooth decay, bad breath. And then proliferating, breeding, outbreeding the others. Outbreeding and out competing for resources. So then the... This has to be taken twice a day. It's chewable tablet daily. And then take it twice a day, morning and evening. Avoid food and drink for 30 minutes. So let it dissolve in your mouth. So over the period of time. And then is this a... When is this available for the market? And what kind of testing do you have to go through? FDA, right? Yeah, food and drug? So your first question is when is it available, right? So it's going to be available... Let's answer them in reverse. So the testing for... Yeah, yeah. Okay. So testing battery will answer the testing word. Okay. So you're asking whether you have to be tested in order to take those? Yeah. So the reason you don't have to do this, this is a dietary supplement. So it is not a drug. And as such, it is supplementing your regular diet and it's helping you. If I make cookies and I want to sell them at Whole Foods, I literally just have to bring my cookies to the buyer at Whole Foods. So yeah. So then similarly, yeah. Okay. Dietary supplement. Yeah. So it is a acknowledged class of the FDA. It is not a drug though. So there's really a class of products called dietary supplements. But then the FDA does have certain measurements on the meat at the grocery store, right? They have these certain foods get... Make sure that they're safe at the grocery store. Right. Yeah. That kind of goes back to what I mentioned earlier. So that dietary supplements, few probiotics in there, they need to be generally recognized as safe. So grass approved, if you will. And so obviously our strengths adhere to that. And there are some other regulations when it comes to the supplement label, certain things that are written on the bottle need to be compliant. And then we do want to see this then on the checkouts right next to the tic-tacs and all that other kind of gums and the gum and all that other kind of stuff. So what's the distribution? When is it available? Yeah, all that good stuff too. Yeah. So it will be available in December. We're directly launching through our website. Awesome. So people will be able to buy at www.oralta.com from December onwards. Gotta love that six character domain name. Yeah. That's so good. Yeah, exactly. And we would like you to enough to get in, get the .com domain as well. Yeah. And then we'll have, we'll have to keep some Oralta on our shelf of product with all the other ones. And so we'll pass it all off to the different people that walk in through the door. Yeah. December, that's quick. Yeah, yeah. It's coming down in December. And also to actually reiterate what Patrick said, it again comes back to the work type of scenario. So there's like few consortia of bad actors that are common across all the people that have bad breath. And we have a consortia of bacteria that will fight this consortia of bacteria that cause bad breath. So, so it, you know, it will, it is efficacious for the majority of people. So it will work for most people, especially. Can I take one right now? Yeah. Well, I mean, it does take some time to dissolve in your mouth. Yeah, that's fine. Okay. How long does it usually take to dissolve like five, 10 minutes? Yeah, that's fine. Oh, when I, when I, when I try, you know, I used to do it like every day, and it took, it took me three months. Maybe I have too much saliva in my mouth. You have lots of, lots of saliva in your mouth. Let's show as, as well as we can what seeing again, here's Oralta, and then here's what the cool. Nice. Pop it in. It's a cherry limeade favorite that you have, I guess. Cherry limeade. Tastes great. But our, our first cherry limeade xylitol, right? Yep. It has, it has xylitol as a sugar, but our first batch has only mint flavor in it. We don't, so there's no cherry limeade or orange or anything. We tried these three things, but our first product that's launching this December is just mint flavor. So, but you are, what you're trying right now is cherry limeade. Which 2019 at some point will be on the website as well. Yeah. I like the model of distribution through website. Is there also interest in the 7-Elevens and the Cascos and what not of the world? Yeah. So, so, like first we'll be selling through our website and trying to build a strong brand, you know, a strong DTC brand. And after that we want to go to Amazon and subsequently go to all these retail pharmaceutical chains. We have quite a bit of interest right now. We will probably go that route, but not in the next few months. Yeah. So, we have a lot of retail pharmaceutical chains that have approached us to actually to see if we would be interested in placing on their shelves. We haven't, I mean, you know, we're talking to them, but it won't happen in the next few months. What do we expect a 60 capsule bottle to retail for on your website? So, it costs $39.97. 40 bucks. 40 bucks. So, like 65 cents a tablet or something, chewable tablet, something like that. Cool. Around that. Okay. Yeah. That's like two bucks a day or a buck of 50 a day or whatever. Yeah. But the thing is, a lot of people who don't have bad breath don't realize it, but bad breath is a citrus issue. It affects people's social, personal and professional lives. You know, like you only know it if you experience it. You know, it's, it causes severe self-esteem and self-confidence issues. That's a good point. Yeah. It has a strong psychological effect too. And I think what I alluded to earlier is also a point that is important to understand that this is not a mint or a mouthwash or something that temporarily masks your bad breath. So, this is really going to the source of the problem and trying to naturally shift your oral microbiome towards a healthy state. So, that also means if, you know, for a day, don't take it, you don't see a difference and you still have good breath, because the microbes live in your mouth. They actively cover all surfaces and prevent the bad bacteria to adhere and basically start growing again. And this effect, you know, depends on the person, might last several days, two weeks. So, it is, it's a very different concept than just buying a box of altos or something. Yes, yes. No one else is going at the source of the bad breath with a chewable tablet. Is that right? No one else is doing that yet? That's exactly right. I thought this was great. I just tried it. I thought it was fantastic. Yeah. Thank you. Yeah, it's a good formulation. Good job. So, I think we covered a pretty good amount of what we needed to talk about. Something, I guess, that I thought was interesting to mention to you guys, to ask you guys about is the, like the further future for Oralta, what does the, you know, the further, further future look like? How many, is this, you know, what are the other Oralta products that you expect to make? Yeah, what's your roadmap look like for a little more? So, our, you know, our first product for bad breath, which isn't right in your hands is launching direct to consumer in December, and we are working on another probiotic for gum disease, which will be launching in Q1 of 2019, and the third one for tooth decay, which will be launching in Q2 of 2019. But what we are also as different chewable tablets that have different compositions of the healthy Exactly. That is correct. But what we're also trying to do is we're also trying to build an Oralta AI platform. So, some select customers who buy through our website will get an option of sending their saliva samples. What we do in a mailer, so if they send us the saliva samples back, we do a sequencing of their saliva samples and send them their reports. So, the advantage of for them to, exactly. So, advantage for them to sending us the saliva samples is a custom formula? No, no, there's not custom formula yet. So, maybe down the line, maybe. So, we're doing free oral microbiome analysis for them. Oh, complete, wait, free? Yeah, exactly. Oh. Yeah. So, and we'll do a free oral microbiome analysis for them, but there's some select customers that buy through our website. Oh, okay. So, once you're a customer for a bit, you can get a free saliva microbiome or a microbiome. So, there'll be an option, like let's say you're a customer, right? You're buying through our website and we'll give an option to send their saliva samples and know more about the oral microbiome. So, you do a lot of science podcasts. You might be interested in knowing how your oral microbiome is. Totally, I have the gut sequence. Exactly. So, we will send you a saliva sampling kit and you can send your saliva samples to us. We sequence your saliva samples and then what we do is we send you back the reports. So, you have this and this particular species of bacteria and over-abundance and the other species in less abundance and what we'll do eventually is, you know, we build a database of these samples and also the sequencing of the microbial profiles of the samples. And what we want to do is eventually use this database to design new therapeutics and refine existing probiotics. This will serve as the core of our future products. So, right now, we have these three things coming out from the experience of the two other co-founders, Jeff and David, but all the future products will be designed by this AI platform that we are building. So, yeah, go ahead. Yeah, just a few things to add on. We also want to learn a little bit more about the people who would send us saliva samples because what's really important is not only their microbiome in terms of DNA sequencing results, but also what are their habits looking like? You know, what is their oral hygiene habit? What are eating habits? Do they have maybe certain, you know, conditions that in the long run, we can correlate with a imbalance of oral microbiome bacteria so that we can really correlate health status and habits with microbiome data, which then really allows us to fine-tune and even develop more targeted probiotics to help, as you, for example, earlier said, different ethnicities or, you know, various other sub-sectors so that they will have much more efficacious probiotics than maybe possibly, which is currently possible. And there is also a recent body of evidence that suggests the link between oral microbiome and systemic diseases like Alzheimer's, you can, and also preterm births, cardiovascular disease. So, this database will help us, you know, connect all these dots. So, how the oral microbiome plays a role in systemic diseases as well. Yeah. Now, give me one more time with all of the oral microbiomes that you will have, all that information, then you can target, help people of different ethnicities, of different compositions of different bad, bad oral microbiomes. Or even geographies, because like, for example, in India, there'll be probably more vegetarians versus here, right? So, they might need a little bit different probiotic versus the people in the United States. Okay. Is there, is there something else? Wait, I also realized, I can't drink water for 30 minutes now. So, what's the reason that you need it to sit, set into, you don't want it to wash down? Yeah. Right. So, ideally, what we recommend is people after their regular oral hygiene routine in the morning and evening, take the tablet, let it dissolve, and then try to go sleep right away. Let basically the good bacteria rehydrate as they are in a dormant state right now. Let them basically rehydrate, start the metabolism, and one of the first things they will do, express certain proteins that allow them to adhere to the surface of the mouth, and thereby starting to compete right away with the existing bad bacteria. And subsequently, they will go through other modes of action to start fighting the bad bacteria. And that just takes some time. So, if you would, for example, just swallow this tablet, you would not get any health benefits. Any health benefits, yeah. This is, this is very different from normal, most of the time people associate probiotics with gut health. You kind of want to swoosh it around your mouth a little even, like move it around from the back corners and yeah. Exactly. And that's exactly what we suggest. And the thing is, one thing we observed consistently is the most ideal time would be to take it right before going to bed. And that gives them six to eight hours to grow and colonize the mouth. That's a great point. And the thing is, and during that time, when you wake up in the morning, there is no longer any biofilm on the teeth and the tongue because these guys who are natural to the mouth are proliferating and growing in the mouth. So, you wake up in the morning feeling clean, actually. That's a really interesting task, too, is to, when I go to bed, take one, wake up in the morning and just, you know, I give that a go. Yeah. So, what you just did is actually, most people do this to try to test their own breath. And it's actually been proven to be very inefficient. Totally. So, you just like, you can't really smell your own breath that well. Yeah. Exactly. So, your nose is kind of used to the smell coming out. So, it's neutral. So, what you really want to do, if you really want to know what your breath and you're alone, because the best test is really have a significant other or friend to smell. You have to remember from the previous day what it smelled like or bottle it up. You can do it yourself if you, so the best thing is you actually lick. Oh, to lick. Like the palm of your hand here and wait maybe 20 seconds and then and then smell. Yeah, mine doesn't smell that good. Or you could come down to our lab and we'll do the test for you. So, we have something called a halimeter, which measures the volatile sulfur compounds in your breath. And we can tell you how about the threshold or how bad your breath is. Interesting. Or how good your breath is. Halimeter. Halimeter. Halimeter. Which measures the halitosis? The halitosis. Halitosis is the medical word for a bad breath. Remember when I was drinking fun of all of you guys at the two days ago at the Indie Bio Roast because I was just, you guys say words like this. Oh yeah, halitosis. You just, the biotech people are so funny. I actually prefer a bad breath tooth decay and gum disease because it's better to communicate that way. And people really understand these situations. If it's a gingivitis, they don't know what, you know, a lot of people don't understand what it is. But a halitosis is what again? It's the bad breath. So, it's the medical term for bad breath. The medical term for it, halitosis. Interesting. Halitosis. Yeah, because sometimes it also makes you feel like, oh, I know what halitosis is. And then you get that superiority ego thing. And if you say bad breath, you get, you know, 95% of people know what that is. Halitosis, 1% of people. I think in Spanish it's called alimiento, which is halitosis. Alimiento? I think so. Interesting. Do you guys, did we cover, was there something else that you thought was important to cover on the show? Um, the direct to consumer launch is happening this December. Please go to www.oralta.com. Links in bio. Exactly. And you click on shop and we will get you, we'll send you the product. And just take one pill in the morning, one pill in the evening. And you'll be able to see the difference in just two weeks. Go ahead and buy and try your product. Maybe we can do like a couple dollar code. Maybe like a 10% off code, something like that. Yeah. So we will send it to you. Maybe you can add that to your YouTube. 10% off and we'll maybe do the code simulation. Fantastic. We'll be the name and then we'll add that to the bio as well. Cool. Simulation viewers will get a 10% discount. Awesome. That's cool. You might want to mention that you can actually already buy the product as a pre-purchase on the website right now. We have already a few hundred people actually on pre-order. Perfect. So if you want to join that group. Congrats. That's good stuff. That would be great. So yeah, we'll throw the code in. It's already ready for pre-order first batch. We'll hopefully get to people before Christmas. That's the plan. Definitely before Christmas. Awesome. What a fun time this has been. Yeah. Do you have another? Yeah. Well, UBI eating all the nice food during Christmas. So save yourself some, get yourself some fresh breath using our Oralta fresh breath probiotic. I love it. This has been so enlightening. Thank you very much for building what you're building and for teaching us about it. This has been a lot of fun. Ladies, if your significant other has bad breath, ask him to buy this product, oralta.com or buy for him. It is so funny. Yeah. Same thing. Same thing for gentlemen. If your lady has bad breath, yeah. Yeah. Like a son or daughter. If your parent has bad breath, yeah. All right. It's taking a lot of money. Taking a lot of money. This has been a lot of fun. It was a lot of money. Thank you, Patrick. What a pleasure. Thanks, everybody. Thanks for tuning in. We greatly appreciate it. Go check out Oralta. Also, if you guys had a good time, give us a comment below to let us know your thoughts about what you think about the product service. Go and build the future. Go and manifest your dreams into the world. Thanks, everyone, for tuning in. Peace out.