 This paper proposes a new framework for characterizing behavioral interventions and linking them to an analysis of the targeted behavior. The framework consists of a behavior system at its center, surrounded by intervention functions and then by policy categories. The behavior system consists of three essential conditions, capability, opportunity and motivation, COMB. The intervention functions are designed to address deficiencies in any of these conditions. Finally, the policy categories are intended to facilitate the implementation of the interventions. The authors have successfully demonstrated the utility of the framework by applying it to two different areas of healthcare, tobacco control and obesity prevention. This article was authored by West Robert, Van Straal and Mark Jem and Mitchie Sisson.