 This study found that certain mutations in melanoma cells were caused by ultraviolet radiation, UVR, induced cyclobutane pyrimidine dimer, CPD, hotspots. The researchers used a new technique called CPD, capture sector identify these mutations and determine their cause. They discovered that some mutations occurred at CPD hotspots, which are areas of increased UVR damage, while others did not. Furthermore, they found that some mutations were caused by ETS-induced CPD hotspots, suggesting that ETS proteins play a role in shaping the mutation landscape of melanoma. This article was authored by Katharazan Selvam, Smithis of Apragasim, Gregory M. K. Poon, and others.