If you are looking for the Best Self-Defense Handgun Ammunition you need to take a look at Winchester PDX1 Defender.
The most impressive demonstration I caught at SHOT Show Media Day, 2012 was the Winchester PDX1 Defender demonstration. With the help of Rob Pincus of ICE Training the folks from Winchester ran an abbreviated FBI Protocol with a 180 gr. .40, a 120 gr. .308 and a 1oz 12 ga slug.
As shown by the video, the results of the various Winchester PDX1 Defender rounds were consistent and the energy delivered to the target was substantial.