 Hi, I'm Alex Salamidis, I'm a neurosurgeon at the Royal Melbourne Hospital and my main interest is cerebral vascular neurosurgery which involves aneurysms and subrachnoid hemorrhage. And an aneurysm is essentially like a blister or a weakness on the blood vessel wall that can rupture at any given time. And there's probably one or two of us in this room which are an unraptured aneurysm that we don't recognize. Once subrachnoid hemorrhage occurs there is lots of blood on the surface of the brain that causes essentially aggravates blood vessels to constrict and that results in essentially ischemia to the brain which can result in stroke or death. Approximately 15% of patients would die at the time of their aneurysm rupture but the majority of our patients would suffer a stroke or die because of vasospasm which is this phenomenon of narrowing of the blood vessels. It happens about 7 or 10 days after the initial bleed. So the plan and our aim and with the help of the Brain Foundation is to identify biomarkers that can predict which patients will go on to develop vasospasms so we could target those patients and treat them prophylactically. We are using microRNAs which are small non-coding RNAs which modulate gene expression and protein transcription and our aim is to identify signatures of microRNAs on admission and thereby identify high risk patients of vasospasms and subsequently our second name is to actually identify therapeutic targets so that with recent techniques known as RNA interference and we are aiming to identify specific genes that can be switched off at will to prevent vasospasms from occurring. So hopefully in one year's time I'll be able to present some of that data. Thank you very much.