 we should definitely avoid of course that they are being infected so what we normally do we put the patient in quarantine for 14 days prior to the administration of CAR-T cell that we test the patient extensively prior to the COVID-19, to the CAR-T cell therapy for COVID-19 infection of course we would never accept a patient for a CAR-T cell trial who has any signs of infection or any hints of a COVID-19 infection but I think with these precautions we are on the very safe side so I think we can do it even if there is COVID-19 still ongoing in most of our countries.