 This meta-analysis found that the accuracy of colpuscopa-directed cervical biopsy is influenced by women's age, menopausal status, and transformation zone type with high-grade squamous interepithelial lesions having better concordance rates than low-grade squamous interepithelial lesions. Further research is needed to analyze the factors correlated with biopsy under diagnosis and overestimation. This article was authored by Hongyang Ren, Mengdejiao, Xu Junjiao, and others.