 Visfertin gnapt is an adipokine released from adipose tissue that has been shown to play a role in the development and progression of atherosclerosis. It is involved in the secretion of cytokines and chemikines, which can lead to increased macrophage survival, leukocyte recruitment by endothelial cells, vascular smooth muscle inflammation, and plaque destabilization. Further research is needed to fully understand the mechanisms mediating the cellular actions of this adipokine and to better characterize the factors regulating its expression and release in various pathological scenarios. This article was authored by Tanya Romacheu, Carlos F. Sanchez Ferre, and Concepcion Perot.