 Natural-based biomaterials are being used to develop new medical products for cutaneous injuries. These materials contain antioxidants that can support an expedite tissue regeneration. However, their low bioavailability limits their therapeutic activity at the injury site. To address this issue, researchers have integrated antioxidant compounds into the biomaterials to maintain their antioxidant activity while facilitating skin tissue recovery. Recent studies have demonstrated the potential of these biomaterials in promoting skin wound healing and tissue regeneration. Clinical trials are needed to further validate the efficacy of these biomaterials. Additionally, we provide an overview of the underlying mechanisms of reactive oxygen species, ROS, generation and discuss the use of ROS scavenging biomaterials in the literature. This article was authored by Nur-Isa M. D. Fadila, Sho-Jean Fang, Nur-Kazaya Kamaruzaman, and others. We are article.tv, links in the description below.