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nanoHUB-U Nanobiosensors L3.6: Sensitivity - Potentiometric Sensors - How to beat Screening

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Published on Feb 19, 2014

Table of Contents:
00:09 Lecture 3.6: Potentiometric Sensors - How to beat Screening
01:42 Outline
02:09 DNA binding and Salt screening
03:54 De-screening at High Frequencies
06:51 Screening is frequency dependent
09:15 Screening is frequency dependent
10:59 Why is the critical frequency?
14:07 Strategy of high frequency descreening
16:02 Outline
16:09 Recall: Nernst Limit of an ISFET
17:36 Amplification with Double-gate FET
20:54 Experimental demonstration for DGFET
22:23 Amplification by a NP-NW Sensors
24:17 Signal to Noise Ratio in a pH amplifier
26:31 Signal to Noise Ratio in a pH-Amplifier
27:27 Conclusions

This video is part of the nanoHUB-U course "Principles of Electronic Nanobiosensors". (https://nanohub.org/courses/PEN)

This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.

For more details see http://nanohub.org/u

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