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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 3.6: Potentiometric Sensors - How to beat Screening 01:42 Outline 02:09 DNA binding and Salt screening 03:54 De-screening at High Frequencies 06:51 Screening is frequency dependent 09:15 Screening is frequency dependent 10:59 Why is the critical frequency? 14:07 Strategy of high frequency descreening 16:02 Outline 16:09 Recall: Nernst Limit of an ISFET 17:36 Amplification with Double-gate FET 20:54 Experimental demonstration for DGFET 22:23 Amplification by a NP-NW Sensors 24:17 Signal to Noise Ratio in a pH amplifier 26:31 Signal to Noise Ratio in a pH-Amplifier 27:27 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.