 This paper discusses a rare genetic disorder caused by a mutation in the gene RAF1. The mutation causes a severe form of progeria, which is characterized by premature aging symptoms such as hair loss, skin wrinkling, and organ failure. The authors also show how the mutation affects the protein structure and function, leading to the observed phenotypes. This article was authored by Samantha Wong, Yuxian Tan, Abigail Yeatinglow, and others.