 The skin healing process involves several steps, including exutative, proliferative, and extracellular matrix remodeling phases. These phases are characterized by the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exutative phenomena that occur after injury lead to the development of tissue edema. Proliferative processes seek to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. Angiogenesis and re-epithelialization also occur at this stage. Endothelial cells are able to differentiate into mesenchymal components, and this differentiation is controlled by a set of signaling proteins called hedgehog. This article was authored by Ana Cristina de Oliveira Gonzalez, Tila Fortuna Costa, Ziltan de Orojo Andrade, and others.