 the 3D organization of chromatin controls gene expression through spatial interactions between genomic locky fish and 3C based methods that are commonly used to study chromatin organization utilize chemical cross-linking a step that may introduce biases in detectable chromatin interactions in their recent study Papantonis and colleagues Brant et al developed alternative new methods of detecting chromatin contacts without the use of chemical cross-linking agents these tools increase the resolution and confidence at which interactions can be identified and may be informative for chromatin interaction dynamics this article was authored by M. Jordan Rowley and Victor G. Courses