 This study found that zinc supplementation can improve sexual and erectile function in rats treated with highly active antiretroviral therapy, heart. The researchers observed that zinc co-treatment increased the latency of mounting, intramission, and ejaculation, as well as the motivation to mate, penile reflex direction, and frequency of mount, intramission, and ejaculation. They also noted that zinc co-treatment reduced the decrease in penile nitric oxide and cyclic guanosine monophosphate, Cgmp, dopamine, and serum testosterone levels caused by heart. Additionally, zinc co-treatment prevented the increase in penile activities of manumene oxidase, acetylcholinesterase, phosphodiesterase-5, and arginase seen in heart-treated rats. Finally, the researchers concluded that zinc supplementation may be beneficial for treating HIV-related sexual and erectile dysfunction.