 Late-onset Alzheimer's disease has a strong genetic component, with heritability ranging from 38% to 66%. However, this figure decreases significantly when the aporegion is excluded or when genome-wide significant regions are removed. Additionally, 13% of the heritability of late-onset Alzheimer's disease can be explained by known genetic loci, while the remaining heritability likely lies around microglial-related genes. This article was authored by Emily Baker, Guna Leonenko, Carl Michael Schmidt, and others.