 We have developed a novel electrochemical apti-sensor for the detection of aflatoxin B1, AFB1. This sensor utilizes a combination of aptimers, which are molecules that bind specifically to their target, and a modified version of a voltage-modulated strip flow, VMSF, device. The aptimers are designed to recognize AFB1, while the VMSF device allows for the selective transport of positively charged molecules such as ruthenium hexamin citrate, RU, and H3, 63+, which is used as a redox probe. When AFB1 is added to the system, it causes the aptimers to bind to it, creating a steric hindrance that prevents RU and H3, 63+, from entering the nano-channel. As a result, the electrochemical signal decreases, indicating the presence of AFB1. The sensor has been tested using both synthetic AFB1 and real samples, demonstrating its accuracy and reliability. This article was authored by TongTong Zhang, Shuisu, Xinyu Lin, and others. We are article.tv, links in the description below.