 The study found that enhanced NFKB signaling in T-cells after they have developed memory to influence a virus boost survival of lung CD8 plus T-cell memory cells. This is done by increasing expression of proteins such as BCL2 and CD122, which help maintain these cells. In contrast, enhanced NFKB signaling during the contraction phase of the response results in fewer lung CD8 plus T-cell memory cells being generated. The researchers also found that this process involves disrupting the balance between two types of T-cell signaling, one involving TGF and another involving NFKB. Blocking NFKB signaling restores the balance and helps generate more lung CD8 plus T-cell memory cells. This article was authored by Curtis J. Pritzle, Desiree Luara, Karen M. Knitzen and others.