 This research has revealed new insights into how certain enzymes called histone acetyltransferases, HATs, are able to selectively use different types of fatty acid chains to modify histones. The study found that one particular type of HAT, KAT2A, can use four different types of fatty acid chains, acetylcoenzyme A, ac-CoA, propionyl-CoA, butyrol-CoA, and succinyl-CoA, to deposit 18 distinctive marks on histones. These marks are important for controlling gene expression and regulating cellular processes. The researchers also determined that the specificity of these fatty acid chains is due to the unique structure of the enzyme's binding site, which allows it to recognize and bind to each type of fatty acid chain. This finding could help scientists better understand how HATs work and how they can be used to control gene expression. This article was authored by Shelley, Manly, Jehe and others. We are article.tv, links in the description below.