 The study aimed to investigate the effects of depeptidilpeptidase 4, DPP4, inhibitor saxagliptin, saxa, on mouse acute lung injury, ALI, induced by lipopolysaccharide, LPS, and the potential mechanisms. The results showed that saxa attenuated LPS-induced pathological injury and edema, decreased oxidative stress markers and inflammatory cytokines, and reduced apoptosis accompanied by alterations in the expression of apoptosis-associated proteins. Additionally, saxa are regulated the expression of NiF2H01 and down-regulated phospho, P, NFB P65 and phospho-inhibitory subunit of NFB alpha, PIB. These findings suggest that saxa alleviates oxidative stress, inflammation, and apoptosis in ALI-induced by LPS via modulating the NiF2H01 and NFB pathways. This article was authored by Kaigua and Fugwang Jin. We are article.tv, links in the description below.