 Graphene has unique physical and chemical properties which makes it ideal for use in sensor technologies. It has been used to immobilize biomolecules such as antibodies, DNA, and enzymes to create highly sensitive and selective biosensors. Methods to attach these biomolecules onto the surface of graphene include covalent bonding, physisorption, and electrochemical detection. Covalent bonding is the most common method due to its simplicity, speed, and high sensitivity. Electrochemical detection is also commonly used due to its ease of use and ability to detect a wide range of analytes. Biosensors using graphene and its derivatives have been developed to detect and identify a variety of diseases, pathogens, and biomolecules linked to diseases. This article was authored by Jan Ayapena Bahamund, Hang N Nguyen, Sophia K. Fannarakis, and others.