At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House (Hugh Laurie) tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson (Robert Sean Leonard).
House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians (Omar Epps, Jennifer Morrison, Jesse Spencer). Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.
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