 The PI3 case MAKT, MTOR signaling pathway plays a crucial role in regulating cellular processes such as proliferation, apoptosis, metabolism, and angiogenesis, and is implicated in various human diseases including ischemic brain injury, neurodegenerative disorders, and tumors. PI3 case MAKT, MTOR signaling pathway inhibitors have shown promising results in preclinical studies, and some have been clinically tested in hematologic malignancies and solid tumors. The review summarizes the research on this pathway, discussing its structural composition, activation, communication processes, regulatory mechanisms, and biological functions in the pathogenesis of neurodegenerative diseases and tumors. This article was authored by Feshu, Lisin-NA, Yin-Fei Li, and others.