 The recent outbreak of COVID-19 has been rapidly spreading globally, with no known vaccine or effective treatment. Clinicians have observed certain risk factors associated with more severe cases of the disease, including existing chronic conditions like hypertension, cardiovascular disease, chronic kidney disease, and diabetes. Additionally, acute cardiac injury and acute kidney injury are also linked to higher mortality rates. More research is needed to understand how best to manage these high-risk patients, as well as to develop supportive therapies to reduce the risk of severe complications. This article was authored by Shinhua Wang, Shihua Xianfeng, Xiao Xiankai, and others.