 Hemocompatibility testing is an essential step in evaluating the safety of medical devices before they can be used in humans. This process involves assessing the potential risk of blood contacting materials by studying how they interact with blood components such as red blood cells, white blood cells, platelets, and clotting factors. The results of these tests help determine whether the device is safe for use in patients. Tests include static, agitated, and shear flow models, which evaluate the effects of different conditions on the device's ability to maintain its integrity while in contact with blood. These tests also measure the amount of hemolysis, destruction of red blood cells, platelet activation, and other indicators of potential complications. Additionally, the surface of the device is evaluated for protein insertion and the formation of thrombosis and fibrin networks. This article was authored by Marbot Weber, Hydron Steinle, Sonja Golembeck, and others.