 This research has demonstrated the potential of a new SCRS-based platform for detecting cancerous exosomes. The point black SCRS substrate was found to be effective in distinguishing between cancerous and healthy exosomes with an accuracy of 83.3% and a specificity of 95.8%. This platform could potentially be used in the clinic for early detection of cancer, allowing for more targeted and personalized treatment options. This article was authored by Shinue Lee, Mysem Keshavars, Paneotis Casanos, and others.