 This paper aims to investigate whether intervention characteristics and persuasive design affected adherence to a web-based intervention. The authors conducted a systematic review of studies into web-based health interventions, coding intervention characteristics, persuasive technology elements, and adherence for each intervention. They found that the typical web-based intervention is meant to be used once a week, includes interaction with the system and a counselor and peers on the web, and some persuasive technology elements. The authors also found that primary task support elements are most commonly employed, while dialogue support and social support are less commonly employed. They found significant differences in intended usage, setup, updates, frequency of interaction with the counselor, the system, and peers, duration, adherence, and the number of primary task support elements between interventions in different healthcare areas. The final regression model explained 55% of the variance in adherence, with increased interaction with the counselor, more frequent intended usage, more frequent updates, and more extensive employment of dialogue support significantly predicting better adherence. The results of this study can be used to make an informed decision about how to design a web-based intervention to which patients are more likely to adhere. This article was authored by Kelders, Sesquia M., Koch, Robin N., Assabard, Hans C., and others. We are article.tv, links in the description below.