 Selective hydrogenalysis of biomass glycerol to propanedule is a promising route for the production of high-value chemicals but remains a challenge. Here, the authors find a PTCU single-atom alloy catalyst exhibits remarkably boosted performance with a turnover frequency value of 2.6 by 103 Mglycerol.multqsa1.h1. This article was authored by Leven Jong, Guichin Kui, Haesong Feng, and others.