 This study examined the relationship between nuclear compartments and CTCF loops, finding that both are important components of chromatin organization. The authors used a combination of high-resolution high-C data, algorithm development, and biophysical modeling to analyze the structure of nuclear compartments and their relationship to CTCF loops. They found that most active promoters and distal enhancers were located within the same compartment, even if the flanking sequences did not overlap. Additionally, they observed that CTCF loops radiating outward from anchor points correlated with strong enhancer promoter interactions and proximity. Finally, they discovered that the diffuse interactions between CTCF loops and other regions of the nucleus depended on the RNA-binding domain of the protein. This study provides new insights into how nuclear compartments and CTCF loops interact and suggests that compartments may be more precise than previously believed.