 The COVID-19 pandemic has caused significant disruption to healthcare services worldwide, including in children. This systematic review aimed to assess the epidemiology and clinical characteristics of pediatric patients with COVID-19. The authors found that males were more likely to be infected with COVID-19 than females, and that lung alterations in chest x-rays were more common than other symptoms or signs. Additionally, laboratory tests showed that multiple organ systems could be affected by the virus. This article was authored by Santiago Vasco Morales, Cristian Santiago Vasco Toa Panta, and Paula Cristina Toa Panta Pinta.