 The SARS-CoV-2-Armachron variant, PA.1, has been spreading rapidly around the globe, but it appears to have lost some of its virulence compared to other strains. This could be due to mutations in the virus's non-structural proteins, which are responsible for replication and viral fitness. These replicants can then be used to test different mutations and determine what exactly makes the Armachron variant less virulent than other strains. This article was authored by Taha White Taha, Irene P. Chen, Jennifer M. Hayoshi, and others.