 Melt-based, solvent-free additive manufacturing techniques have enabled the production of biodegradable polymeric scaffolds with customizable architectures for tissue engineering applications. The mechanical, biological properties of these scaffolds are highly dependent on their structural organization and can be regulated through design strategies to optimize in vitro and in vivo performance. Clinical trials have shown promising results, but challenges remain in terms of scalability and reproducibility. This article was authored by Zijun Meng, Zhen Kang He, Justin Li, and others.