 then drivers are a type of polymeric structure that can be used as drug delivery vehicles or as vectors for gene therapy. They have a defined structure which allows them to interact with drugs and biomolecules such as proteins and DNA. Their unique properties make them attractive candidates for various biomedical applications including drug delivery and gene therapy. However, their use is limited due to toxicity concerns. This review discusses the synthesis, drug delivery and targeting, gene delivery and characterization of dendrimers as well as the toxicity issues associated with them and possible solutions to mitigate those risks.